Voltage-gated potassium channel KCNC1

BE0004723ProteinHumansKCNC1

Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298, PubMed:35840580). It is acted on by 2 drugs in DrugBank.

Gene name
KCNC1
UniProtKB entry
P48547Swiss-Prot
Cellular location
Cell membrane
Residues / weight
511 residues · 57,942 Da
Also known as
NGK2 · Potassium voltage-gated channel subfamily C member 1 · Voltage-gated potassium channel subunit Kv3.1 · Voltage-gated potassium channel subunit Kv4

Resolves to

Protein
UniProtP48547UniProt nameKCNC1_HUMAN
Gene
HGNCHGNC:6233NCBI Gene3746GeneCardsKCNC1
Pharmacology
KEGGhsa:3746
Structure
PDB7PHHPDB7PHIPDB7PHK
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-gated potassium channel KCNC1, how selective are they, and which programs against it are still in active trials?

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