RNA polymerase sigma factor SigA

BE0004732ProteinClostridium difficile (strain 630)sigA1

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. It is acted on by 1 drug in DrugBank.

Gene name
sigA1
UniProtKB entry
Q18BX5TrEMBL
Cellular location
Cytoplasm
Residues / weight
390 residues · 44,426 Da
Also known as
sigA

Resolves to

Protein
UniProtQ18BX5UniProt nameQ18BX5_CLOD6
Gene
NCBI Gene4915727
Pharmacology
KEGGcdf:CD630_14550
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on RNA polymerase sigma factor SigA, how selective are they, and which programs against it are still in active trials?

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