Interleukin-1 alpha

BE0004734ProteinHumansIL1A

Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). It is acted on by 5 drugs in DrugBank.

Gene name
IL1A
UniProtKB entry
P01583Swiss-Prot
Cellular location
Nucleus
Residues / weight
271 residues · 30,606 Da
Also known as
Hematopoietin-1 · IL-1 alpha · IL1F1

Resolves to

Protein
UniProtP01583UniProt nameIL1A_HUMAN
Gene
HGNCHGNC:5991NCBI Gene3552GeneCardsIL1A
Pharmacology
KEGGhsa:3552
Structure
PDB2ILAPDB2KKIPDB2L5X
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-1 alpha, how selective are they, and which programs against it are still in active trials?

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