Interleukin-1 receptor antagonist protein

BE0004735ProteinHumansIL1RN

Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. It is acted on by 1 drug in DrugBank.

Gene name
IL1RN
UniProtKB entry
P18510Swiss-Prot
Cellular location
Secreted
Residues / weight
177 residues · 20,055 Da
Also known as
ICIL-1RA · IL-1ra · IL-1RN · IL1 inhibitor · IL1F3

Resolves to

Protein
UniProtP18510UniProt nameIL1RA_HUMAN
Gene
HGNCHGNC:6000NCBI Gene3557GeneCardsIL1RN
Pharmacology
KEGGhsa:3557
Structure
PDB1ILRPDB1ILTPDB1IRA
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-1 receptor antagonist protein, how selective are they, and which programs against it are still in active trials?

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