Proteasome subunit beta type-9

BE0004737ProteinHumansPSMB9

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (PubMed:33727065,... It is acted on by 1 drug in DrugBank.

Gene name
PSMB9
UniProtKB entry
P28065Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
219 residues · 23,264 Da
Also known as
3.4.25.1 · LMP2 · Low molecular mass protein 2 · Macropain chain 7 · Multicatalytic endopeptidase complex chain 7

Resolves to

Protein
UniProtP28065UniProt namePSB9_HUMAN
Gene
HGNCHGNC:9546NCBI Gene5698GeneCardsPSMB9
Pharmacology
IUPHAR/GtoPdb2409KEGGhsa:5698
Structure
PDB6AVOPDB6E5BPDB7AWE
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proteasome subunit beta type-9, how selective are they, and which programs against it are still in active trials?

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