Proteasome subunit beta type-10
Details
- Name
- Proteasome subunit beta type-10
- Kind
- protein
- Synonyms
- 3.4.25.1
- LMP10
- Low molecular mass protein 10
- Macropain subunit MECl-1
- MECL1
- Multicatalytic endopeptidase complex subunit MECl-1
- Proteasome MECl-1
- Proteasome subunit beta-2i
- Gene Name
- PSMB10
- UniProtKB Entry
- P40306Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0020795|Proteasome subunit beta type-10 MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
- Number of residues
- 273
- Molecular Weight
- 28936.08
- Theoretical pI
- Not Available
- GO Classification
- Functionsendopeptidase activity / threonine-type endopeptidase activityProcesseshumoral immune response / proteasome-mediated ubiquitin-dependent protein catabolic process / T cell proliferationComponentscytosol / nucleoplasm / proteasome complex / proteasome core complex / spermatoproteasome complex
- General Function
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
- Specific Function
- endopeptidase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0020796|Proteasome subunit beta type-10 (PSMB10) ATGCTGAAGCCAGCCCTGGAGCCCCGAGGGGGCTTCTCCTTCGAGAACTGCCAAAGAAAT GCATCATTGGAACGCGTCCTCCCGGGGCTCAAGGTCCCTCACGCACGCAAGACCGGGACC ACCATCGCGGGCCTGGTGTTCCAAGACGGGGTCATTCTGGGCGCCGATACGCGAGCCACT AACGATTCGGTCGTGGCGGACAAGAGCTGCGAGAAGATCCACTTCATCGCCCCCAAAATC TACTGCTGTGGGGCTGGAGTAGCCGCGGACGCCGAGATGACCACACGGATGGTGGCGTCC AAGATGGAGCTACACGCGTTATCTACGGGCCGCGAGCCCCGCGTGGCCACGGTCACTCGC ATCCTGCGCCAGACGCTCTTCAGGTACCAGGGCCACGTGGGTGCATCGCTGATCGTGGGC GGCGTAGACCTGACTGGACCGCAGCTCTACGGTGTGCATCCCCATGGCTCCTACAGCCGT CTGCCCTTCACAGCCCTGGGCTCTGGTCAGGACGCGGCCCTGGCGGTGCTAGAAGACCGG TTCCAGCCGAACATGACGCTGGAGGCTGCTCAGGGGCTGCTGGTGGAAGCCGTCACCGCC GGGATCTTGGGTGACCTGGGCTCCGGGGGCAATGTGGACGCATGTGTGATCACAAAGACT GGCGCCAAGCTGCTGCGGACACTGAGCTCACCCACAGAGCCCGTGAAGAGGTCTGGCCGC TACCACTTTGTGCCTGGAACCACAGCTGTCCTGACCCAGACAGTGAAGCCACTAACCCTG GAGCTAGTGGAGGAAACTGTGCAGGCTATGGAGGTGGAGTAA
- Chromosome Location
- 16
- Locus
- 16q22.1
- External Identifiers
Resource Link UniProtKB ID P40306 UniProtKB Entry Name PSB10_HUMAN GeneCard ID PSMB10 HGNC ID HGNC:9538 PDB ID(s) 6AVO, 6E5B, 6HV3, 6HV4, 6HV5, 6HV7, 6HVA, 6HVR, 6HVS, 6HVT, 6HVU, 6HVV, 6HVW, 7AWE, 7B12 KEGG ID hsa:5699 NCBI Gene ID 5699 - General References
- Larsen F, Solheim J, Kristensen T, Kolsto AB, Prydz H: A tight cluster of five unrelated human genes on chromosome 16q22.1. Hum Mol Genet. 1993 Oct;2(10):1589-95. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Carfilzomib approved, investigational yes target inhibitor Details