Proteasome subunit beta type-10

Details

Name
Proteasome subunit beta type-10
Kind
protein
Synonyms
  • 3.4.25.1
  • LMP10
  • Low molecular mass protein 10
  • Macropain subunit MECl-1
  • MECL1
  • Multicatalytic endopeptidase complex subunit MECl-1
  • Proteasome MECl-1
  • Proteasome subunit beta-2i
Gene Name
PSMB10
UniProtKB Entry
P40306Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0020795|Proteasome subunit beta type-10
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
Number of residues
273
Molecular Weight
28936.08
Theoretical pI
Not Available
GO Classification
Functions
endopeptidase activity / threonine-type endopeptidase activity
Processes
humoral immune response / proteasome-mediated ubiquitin-dependent protein catabolic process / T cell proliferation
Components
cytosol / nucleoplasm / proteasome complex / proteasome core complex / spermatoproteasome complex
General Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
Specific Function
endopeptidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0020796|Proteasome subunit beta type-10 (PSMB10)
ATGCTGAAGCCAGCCCTGGAGCCCCGAGGGGGCTTCTCCTTCGAGAACTGCCAAAGAAAT
GCATCATTGGAACGCGTCCTCCCGGGGCTCAAGGTCCCTCACGCACGCAAGACCGGGACC
ACCATCGCGGGCCTGGTGTTCCAAGACGGGGTCATTCTGGGCGCCGATACGCGAGCCACT
AACGATTCGGTCGTGGCGGACAAGAGCTGCGAGAAGATCCACTTCATCGCCCCCAAAATC
TACTGCTGTGGGGCTGGAGTAGCCGCGGACGCCGAGATGACCACACGGATGGTGGCGTCC
AAGATGGAGCTACACGCGTTATCTACGGGCCGCGAGCCCCGCGTGGCCACGGTCACTCGC
ATCCTGCGCCAGACGCTCTTCAGGTACCAGGGCCACGTGGGTGCATCGCTGATCGTGGGC
GGCGTAGACCTGACTGGACCGCAGCTCTACGGTGTGCATCCCCATGGCTCCTACAGCCGT
CTGCCCTTCACAGCCCTGGGCTCTGGTCAGGACGCGGCCCTGGCGGTGCTAGAAGACCGG
TTCCAGCCGAACATGACGCTGGAGGCTGCTCAGGGGCTGCTGGTGGAAGCCGTCACCGCC
GGGATCTTGGGTGACCTGGGCTCCGGGGGCAATGTGGACGCATGTGTGATCACAAAGACT
GGCGCCAAGCTGCTGCGGACACTGAGCTCACCCACAGAGCCCGTGAAGAGGTCTGGCCGC
TACCACTTTGTGCCTGGAACCACAGCTGTCCTGACCCAGACAGTGAAGCCACTAACCCTG
GAGCTAGTGGAGGAAACTGTGCAGGCTATGGAGGTGGAGTAA
Chromosome Location
16
Locus
16q22.1
External Identifiers
ResourceLink
UniProtKB IDP40306
UniProtKB Entry NamePSB10_HUMAN
GeneCard IDPSMB10
HGNC IDHGNC:9538
PDB ID(s)6AVO, 6E5B, 6HV3, 6HV4, 6HV5, 6HV7, 6HVA, 6HVR, 6HVS, 6HVT, 6HVU, 6HVV, 6HVW, 7AWE, 7B12
KEGG IDhsa:5699
NCBI Gene ID5699
General References
  1. Larsen F, Solheim J, Kristensen T, Kolsto AB, Prydz H: A tight cluster of five unrelated human genes on chromosome 16q22.1. Hum Mol Genet. 1993 Oct;2(10):1589-95. [Article]
  2. Foss GS, Larsen F, Solheim J, Prydz H: Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. Biochim Biophys Acta. 1998 Mar 12;1402(1):17-28. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  5. Hisamatsu H, Shimbara N, Saito Y, Kristensen P, Hendil KB, Fujiwara T, Takahashi E, Tanahashi N, Tamura T, Ichihara A, Tanaka K: Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. J Exp Med. 1996 Apr 1;183(4):1807-16. [Article]
  6. Foss GS, Prydz H: Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1. J Biol Chem. 1999 Dec 3;274(49):35196-202. [Article]
  7. Hallermalm K, Seki K, Wei C, Castelli C, Rivoltini L, Kiessling R, Levitskaya J: Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface. Blood. 2001 Aug 15;98(4):1108-15. [Article]
  8. Li J, Schuler-Thurner B, Schuler G, Huber C, Seliger B: Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation. Int Immunol. 2001 Dec;13(12):1515-23. [Article]
  9. Apcher GS, Heink S, Zantopf D, Kloetzel PM, Schmid HP, Mayer RJ, Kruger E: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. FEBS Lett. 2003 Oct 9;553(1-2):200-4. [Article]
  10. Raghavendra Prasad HS, Qi Z, Srinivasan KN, Gopalakrishnakone P: Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. Toxicon. 2004 Nov;44(6):597-608. [Article]
  11. Namiki S, Nakamura T, Oshima S, Yamazaki M, Sekine Y, Tsuchiya K, Okamoto R, Kanai T, Watanabe M: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett. 2005 May 23;579(13):2781-7. Epub 2005 Apr 20. [Article]
  12. Wu F, Dassopoulos T, Cope L, Maitra A, Brant SR, Harris ML, Bayless TM, Parmigiani G, Chakravarti S: Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. Inflamm Bowel Dis. 2007 Jul;13(7):807-21. [Article]
  13. Moschonas A, Kouraki M, Knox PG, Thymiakou E, Kardassis D, Eliopoulos AG: CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol. 2008 Oct;28(20):6208-22. doi: 10.1128/MCB.00611-08. Epub 2008 Aug 11. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Carfilzomibapproved, investigationalyestargetinhibitorDetails