Proteasome subunit beta type-10

BE0004738ProteinHumansPSMB10

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It is acted on by 1 drug in DrugBank.

Gene name
PSMB10
UniProtKB entry
P40306Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
273 residues · 28,936 Da
Also known as
3.4.25.1 · LMP10 · Low molecular mass protein 10 · Macropain subunit MECl-1 · MECL1

Resolves to

Protein
UniProtP40306UniProt namePSB10_HUMAN
Gene
HGNCHGNC:9538NCBI Gene5699GeneCardsPSMB10
Pharmacology
KEGGhsa:5699
Structure
PDB6AVOPDB6E5BPDB6HV3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
16GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Proteasome subunit beta type-10, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In