Proteasome subunit beta type-8

BE0004739ProteinHumansPSMB8

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It is acted on by 1 drug in DrugBank.

Gene name
PSMB8
UniProtKB entry
P28062Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
276 residues · 30,354 Da
Also known as
3.4.25.1 · LMP7 · Low molecular mass protein 7 · Macropain subunit C13 · Multicatalytic endopeptidase complex subunit C13

Resolves to

Protein
UniProtP28062UniProt namePSB8_HUMAN
Gene
HGNCHGNC:9545NCBI Gene5696GeneCardsPSMB8
Pharmacology
IUPHAR/GtoPdb2408KEGGhsa:5696
Structure
PDB5L5APDB5L5BPDB5L5D
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proteasome subunit beta type-8, how selective are they, and which programs against it are still in active trials?

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