Protective antigen

BE0004747ProteinBacillus anthracispagA

Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm (PubMed:11700562, PubMed:14507921, PubMed:15243628,... It is acted on by 5 drugs in DrugBank.

Gene name
pagA
UniProtKB entry
P13423Swiss-Prot
Cellular location
Secreted
Residues / weight
764 residues · 85,810 Da
Also known as
Anthrax toxins translocating protein · PA · PA-83 · PA83 · pag

Resolves to

Protein
UniProtP13423UniProt namePAG_BACAN
Gene
NCBI Gene3361714
Pharmacology
KEGGbar:GBAA_pXO1_0164
Structure
PDB1ACCPDB1T6BPDB1TX5
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protective antigen, how selective are they, and which programs against it are still in active trials?

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