ATP-binding cassette sub-family G member 5

BE0004750ProteinHumansABCG5

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). It is acted on by 3 drugs in DrugBank.

Gene name
ABCG5
UniProtKB entry
Q9H222Swiss-Prot
Cellular location
Cell membrane
Residues / weight
651 residues · 72,503 Da
Also known as
7.6.2.- · Sterolin-1

Resolves to

Protein
UniProtQ9H222UniProt nameABCG5_HUMAN
Gene
HGNCHGNC:13886NCBI Gene64240GeneCardsABCG5
Pharmacology
KEGGhsa:64240
Structure
PDB5DO7PDB7JR7PDB7R87
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family G member 5, how selective are they, and which programs against it are still in active trials?

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