ATP-binding cassette sub-family G member 8

BE0004751ProteinHumansABCG8

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. It is acted on by 3 drugs in DrugBank.

Gene name
ABCG8
UniProtKB entry
Q9H221Swiss-Prot
Cellular location
Cell membrane
Residues / weight
673 residues · 75,678 Da
Also known as
7.6.2.- · Sterolin-2

Resolves to

Protein
UniProtQ9H221UniProt nameABCG8_HUMAN
Gene
HGNCHGNC:13887NCBI Gene64241GeneCardsABCG8
Pharmacology
KEGGhsa:64241
Structure
PDB5DO7PDB7JR7PDB7R87
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family G member 8, how selective are they, and which programs against it are still in active trials?

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