Adenylate kinase 4, mitochondrial

BE0004780ProteinHumansAK4

Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). It is acted on by 2 drugs in DrugBank.

Gene name
AK4
UniProtKB entry
P27144Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
223 residues · 25,268 Da
Also known as
2.7.4.4 · 2.7.4.6 · Adenylate kinase 3-like · AK3 · AK3L1

Resolves to

Protein
UniProtP27144UniProt nameKAD4_HUMAN
Gene
HGNCHGNC:363NCBI Gene205GeneCardsAK4
Pharmacology
KEGGhsa:205
Structure
PDB2AR7PDB2BBWPDB3NDP
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenylate kinase 4, mitochondrial, how selective are they, and which programs against it are still in active trials?

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