Secreted aspartic protease 2

BE0004793ProteinYeastSAP2

Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:12761103, PubMed:15820985, PubMed:15845479, PubMed:19880183, PubMed:20713630, PubMed:22302440, PubMed:23927842). It is acted on by 5 drugs in DrugBank.

Gene name
SAP2
UniProtKB entry
P0DJ06Swiss-Prot
Cellular location
Secreted
Residues / weight
398 residues · 42,316 Da
Also known as
3.4.23.24 · ACP 2 · Aspartate protease 2 · Candidapepsin-2 · PEP11

Resolves to

Protein
UniProtP0DJ06UniProt nameCARP2_CANAL
Gene
NCBI Gene3647333GenBank170841
Pharmacology
KEGGcal:CaO19.11193
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Secreted aspartic protease 2, and which indications are they being tested in?

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