Thymidylate synthase 1

BE0004794ProteinBacillus subtilis (strain 168)thyA1

Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. It is acted on by 1 drug in DrugBank.

Gene name
thyA1
UniProtKB entry
P0CI79Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
279 residues · 32,807 Da
Also known as
2.1.1.45 · Thymidylate synthase A · TS 1 · TS A · TSase A

Resolves to

Protein
UniProtP0CI79UniProt nameTYSY1_BACSU
Gene
NCBI Gene939555GenBank607048
Pharmacology
KEGGbsu:BSU17680
Structure
PDB1B02PDB1BKOPDB1BKP
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thymidylate synthase 1, and which indications are they being tested in?

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