3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

BE0004877ProteinHumansEBP

Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers a catalytic step in the postlanosterol biosynthesis of cholesterol. It is acted on by 3 drugs in DrugBank.

Gene name
EBP
UniProtKB entry
Q15125Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
230 residues · 26,353 Da
Also known as
5.3.3.5 · Cholestenol Delta-isomerase · Cholesterol-5,6-epoxide hydrolase subunit EBP · D8-D7 sterol isomerase · Delta(8)-Delta(7) sterol isomerase

Resolves to

Protein
UniProtQ15125UniProt nameEBP_HUMAN
Gene
HGNCHGNC:3133NCBI Gene10682GeneCardsEBP
Pharmacology
KEGGhsa:10682
Structure
PDB6OHTPDB6OHUPDB8W0R
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, how selective are they, and which programs against it are still in active trials?

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