5-hydroxytryptamine receptor 2C
Details
- Name
- 5-hydroxytryptamine receptor 2C
- Kind
- protein
- Synonyms
- 5-HT-1C
- 5-HT-2C
- 5-HT1C
- 5-hydroxytryptamine receptor 1C
- 5ht1c
- Htr1c
- Serotonin receptor 2C
- Gene Name
- Htr2c
- UniProtKB Entry
- P08909Swiss-Prot
- Organism
- Rat
- NCBI Taxonomy ID
- 10116
- Amino acid sequence
>lcl|BSEQ0021418|5-hydroxytryptamine receptor 2C MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
- Number of residues
- 460
- Molecular Weight
- 51916.005
- Theoretical pI
- Not Available
- GO Classification
- FunctionsGq/11-coupled serotonin receptor activity / serotonin receptor activityProcessesbehavioral fear response / behavioral response to nicotine / feeding behavior / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / inositol phosphate-mediated signaling / locomotory behavior / negative regulation of dopamine metabolic process / negative regulation of locomotion / organ regeneration / phospholipase C-activating serotonin receptor signaling pathway / phospholipase D-activating G-protein coupled receptor signaling pathway / positive regulation of acetylcholine secretion, neurotransmission / positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway / positive regulation of gamma-aminobutyric acid secretion / positive regulation of vasoconstriction / regulation of appetite / regulation of corticotropin-releasing hormone secretion / regulation of neurological system process / regulation of sensory perception of pain / response to drugComponentscell surface / cytosol / external side of plasma membrane / integral component of plasma membrane / intracellular
- General Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
- Specific Function
- 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- 1-32
- Transmembrane Regions
- 54-79 91-111 129-151 172-194 215-236 314-335 351-373
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0021419|5-hydroxytryptamine receptor 2C (Htr2c) ATGGTGAACCTTGGCAACGCGGTGCGCTCGCTCCTGATGCACCTAATCGGCCTATTGGTT TGGCAATTCGATATTTCCATAAGTCCAGTAGCAGCTATAGTAACTGACACTTTTAATTCC TCCGATGGTGGACGCTTGTTTCAATTCCCGGACGGGGTACAAAACTGGCCAGCACTTTCA ATCGTCGTGATTATAATCATGACAATAGGGGGCAACATTCTTGTTATCATGGCAGTAAGC ATGGAGAAGAAACTGCACAATGCAACCAATTACTTCTTAATGTCCCTAGCCATTGCTGAT ATGCTGGTGGGACTACTTGTCATGCCCCTGTCCCTGCTTGCTATTCTTTATGATTATGTC TGGCCTTTACCTAGATATTTGTGCCCCGTCTGGATTTCACTAGATGTGCTATTTTCAACT GCGTCCATCATGCACCTCTGCGCCATATCGCTGGACCGGTATGTAGCAATACGTAATCCT ATTGAGCATAGCCGGTTCAATTCGCGGACTAAGGCCATCATGAAGATTGCCATCGTTTGG GCAATATCAATAGGAGTTTCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAAGCAAA GTGTTCGTGAATAACACCACGTGCGTGCTCAATGACCCCAACTTCGTTCTCATCGGGTCC TTCGTGGCATTCTTCATCCCGTTGACGATTATGGTGATCACCTACTTCTTAACGATCTAC GTCCTGCGCCGTCAAACTCTGATGTTACTTCGAGGTCACACCGAGGAGGAACTGGCTAAT ATGAGCCTGAACTTTCTGAACTGCTGCTGCAAGAAGAATGGTGGTGAGGAAGAGAACGCT CCGAACCCTAATCCAGATCAGAAACCACGTCGAAAGAAGAAAGAAAAGCGTCCCAGAGGC ACCATGCAAGCTATCAACAACGAAAAGAAAGCTTCCAAAGTCCTTGGCATTGTATTCTTT GTGTTTCTGATCATGTGGTGCCCGTTTTTCATCACCAATATCCTGTCGGTTCTTTGTGGG AAGGCCTGTAACCAAAAGCTAATGGAGAAGCTTCTCAATGTGTTTGTGTGGATTGGCTAT GTGTGTTCAGGCATCAATCCTCTGGTGTACACTCTCTTTAATAAAATTTACCGAAGGGCT TTCTCTAAATATTTGCGCTGCGATTATAAGCCAGACAAAAAGCCTCCTGTTCGACAGATT CCTAGGGTTGCTGCCACTGCTTTGTCTGGGAGGGAGCTCAATGTTAACATTTATCGGCAT ACCAATGAACGTGTGGCTAGGAAAGCTAATGACCCTGAGCCTGGCATAGAGATGCAGGTG GAGAACTTAGAGCTGCCAGTCAACCCCTCTAATGTGGTCAGCGAGAGGATTAGTAGTGTG TAA
- Chromosome Location
- X
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08909 UniProtKB Entry Name 5HT2C_RAT PDB ID(s) 2MHO KEGG ID rno:25187 IUPHAR/Guide To Pharmacology ID 8 NCBI Gene ID 25187 - General References
- Julius D, MacDermott AB, Axel R, Jessell TM: Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science. 1988 Jul 29;241(4865):558-64. [Article]
- Parker LL, Backstrom JR, Sanders-Bush E, Shieh BH: Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1. J Biol Chem. 2003 Jun 13;278(24):21576-83. Epub 2003 Apr 7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nortriptyline approved unknown target antagonist Details Trimipramine approved unknown target binder Details Amitriptyline approved unknown target antagonist Details Trazodone approved, investigational unknown target antagonistpartial agonist Details Oxymetazoline approved, investigational unknown target partial agonist Details