Acetylcholine receptor subunit alpha-type unc-63
Details
- Name
- Acetylcholine receptor subunit alpha-type unc-63
- Kind
- protein
- Synonyms
- lev-7
- Levamisole-resistant protein 7
- Uncoordinated protein 63
- Gene Name
- unc-63
- UniProtKB Entry
- Q9N587Swiss-Prot
- Organism
- Caenorhabditis elegans
- NCBI Taxonomy ID
- 6239
- Amino acid sequence
>lcl|BSEQ0013366|Acetylcholine receptor subunit alpha-type unc-63 MGPNDHGFAYILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKL SQLLDVHEKNQIMTTNVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNAD GNYQVTIMTKAKLTYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVD LQHRDKHLEKEIEEDVEGVDGPTKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYP CCESPFIDITYEIHLRRKTLFYTVNLIFPSVGISFLTALVFYLPSDGGEKISLCISILIS LTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVTLSVVVTVVTLNVHYRSPTTHTMPKWM KRLFVDFLPKYLLMTRPQPPGHHSKPNRKFDSRASTFSIGVNHVLGQNSELLSPGLNSNR EESSFTLPRDNSPVRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITFTFAC AFGTVVIIARAPSIYDNTPALA
- Number of residues
- 502
- Molecular Weight
- 57390.645
- Theoretical pI
- Not Available
- GO Classification
- Functionsacetylcholine-activated cation-selective channel activity / acetylcholine-gated cation channel activityProcessescalcium ion import across plasma membrane / cation transmembrane transport / ion transmembrane transport / locomotion / neurological system process / neuromuscular synaptic transmission / post-embryonic development / regulation of locomotion / regulation of membrane potential / regulation of oviposition / response to nicotine / signal transduction / synaptic transmission, cholinergicComponentsacetylcholine-gated channel complex / cell junction / intracellular / neuromuscular junction / neuron projection / plasma membrane / postsynaptic membrane
- General Function
- Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15280391, PubMed:15990870, PubMed:20027209). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209). Involved in nAChR sensitivity to nicotine and levamisole (PubMed:15280391, PubMed:15990870).
- Specific Function
- acetylcholine-gated monoatomic cation-selective channel activity
- Pfam Domain Function
- Signal Regions
- 1-23
- Transmembrane Regions
- 264-284 293-313 326-346 471-491
- Cellular Location
- Cell junction
- Gene sequence
>lcl|BSEQ0013367|Acetylcholine receptor subunit alpha-type unc-63 (unc-63) ATGGGACCAAATGACCACGGTTTTGCGTACATCCTCATATTTCTGCTCCTCTCTCCACCA ACACATGCGAACAGAGATGCGAATCGGTTATTTGAGGATCTTATCGCAGATTACAATAAA CTGGTGCGACCGGTCAGTGAAAACGGAGAGACACTCGTGGTGACGTTCAAATTAAAATTA AGTCAATTATTAGATGTTCATGAAAAGAATCAGATTATGACAACAAATGTCTGGTTACAA CATAGCTGGATGGACTACAAACTTCGATGGGATCCAGTAGAATATGGTGGTGTAGAAGTA CTGTATGTTCCATCAGATACCATTTGGCTACCTGACGTTGTTTTATATAATAATGCCGAT GGAAATTATCAAGTTACAATTATGACAAAAGCAAAGCTGACATATAATGGAACAGTTGAA TGGGCACCGCCTGCGATCTATAAAAGCATGTGCCAAATCGACGTTGAATTCTTTCCATTT GACCGTCAACAATGTGAAATGAAATTTGGATCATGGACATATGGAGGATTAGAAGTTGAT CTACAACATAGAGACAAACATTTGGAAAAAGAAATTGAAGAAGACGTTGAAGGTGTTGAT GGCCCAACAAAAGAAATTGTATGGGTTGTTGATAGAGGAATTGATTTAAGTGATTATTAT CCATCTGTCGAATGGGATATTTTAAATGTTCCCGGAAAAAGGCATTCCAAGCGATACCCA TGTTGCGAAAGTCCATTCATAGACATCACATACGAGATTCATCTTCGAAGGAAAACGTTA TTCTACACAGTAAATCTAATATTCCCTTCAGTTGGAATCAGTTTTCTCACGGCACTTGTA TTCTATCTACCATCGGATGGAGGTGAAAAAATCTCACTTTGTATTTCGATTCTTATCTCG TTGACTGTTTTCTTCCTTCTGCTCGTAGAGATTATTCCATCAACATCACTTGTGATTCCA TTAATTGGAAAATATCTTCTATTTACAATGGTTCTTGTCACATTATCTGTGGTGGTTACT GTAGTTACATTGAATGTACATTATCGATCCCCAACAACACATACAATGCCAAAATGGATG AAGCGGTTATTCGTGGATTTTCTGCCAAAATATCTTCTCATGACACGACCGCAACCTCCT GGTCATCATAGCAAACCAAATCGGAAGTTCGACTCCCGTGCATCAACATTCAGTATTGGA GTGAATCATGTATTGGGACAGAATTCTGAATTATTATCACCAGGACTCAATTCCAATAGG GAAGAGTCTTCATTTACTTTACCACGCGACAACTCGCCAGTTCGATCTGCTGTCGAAAGT GTTGCCTATATAGCGGATCATTTGAAAAACGAGGAAGATGATAAACAGGTAATCGAGGAC TGGAAATACATATCAGTCGTCATGGATCGAATATTTTTAATCACATTCACTTTTGCTTGT GCTTTTGGAACCGTTGTGATTATTGCACGTGCACCGTCCATTTACGATAACACGCCGGCT CTTGCTTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9N587 UniProtKB Entry Name ACH6_CAEEL KEGG ID cel:CELE_Y110A7A.3 NCBI Gene ID 172150 - General References
- Culetto E, Baylis HA, Richmond JE, Jones AK, Fleming JT, Squire MD, Lewis JA, Sattelle DB: The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. J Biol Chem. 2004 Oct 8;279(41):42476-83. Epub 2004 Jul 27. [Article]
- Authors unspecified: Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. [Article]
- Kaji H, Kamiie J, Kawakami H, Kido K, Yamauchi Y, Shinkawa T, Taoka M, Takahashi N, Isobe T: Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol Cell Proteomics. 2007 Dec;6(12):2100-9. Epub 2007 Aug 30. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Levamisole approved, investigational, vet_approved, withdrawn unknown target activator Details