Acetylcholine receptor subunit beta-type lev-1
Details
- Name
- Acetylcholine receptor subunit beta-type lev-1
- Kind
- protein
- Synonyms
- Levamisole-resistant protein 1
- Gene Name
- lev-1
- UniProtKB Entry
- Q27218Swiss-Prot
- Organism
- Caenorhabditis elegans
- NCBI Taxonomy ID
- 6239
- Amino acid sequence
>lcl|BSEQ0017564|Acetylcholine receptor subunit beta-type lev-1 MMLGGGGGCGAGGTWLGFLVFLAVSLRNHSTCEDIDAEDRLMVDLFRGYNSLVQPVRNRS ELPMIVKIGMQLVLLINVDEKEQVMHTNVWLTMKWDDFQLKWDPRDYANITQIRVAPEKV WLPDIVLFNNADGNYEVSFMCNVLILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLT FGSWTYNRDEIKLDFLTSDRVDFSEYSTSSIWDMMDGPAVLTSDRSRIEFQIRIRRKTLF YTVVLILPTVLMAFLNVTVFYLPTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPL VAKYLLLTFVLNIITIMVTTIICNIYFRSPITHRLPPWVRKVFLDILPLLMCMQRPHRKN VIQRSHRRLLETGPSVEENPMRSGEHHPLCRHTHNQDSCRRVRIQSDELDDELSPEAQRA IDAIEFITENRRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVFET FDENATLVKLKQLYDMGLANDTVLGIF
- Number of residues
- 507
- Molecular Weight
- 58025.88
- Theoretical pI
- Not Available
- GO Classification
- Functionsacetylcholine-activated cation-selective channel activityProcessescation transmembrane transport / inorganic cation transmembrane transport / neurological system process / neuromuscular synaptic transmission / regulation of locomotion / regulation of membrane potential / regulation of oviposition / response to nicotine / signal transduction / synaptic transmission, cholinergicComponentsacetylcholine-gated channel complex / cell junction / neuron projection / neuronal cell body / postsynaptic membrane
- General Function
- Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine.
- Specific Function
- acetylcholine-gated monoatomic cation-selective channel activity
- Pfam Domain Function
- Signal Regions
- 1-31
- Transmembrane Regions
- 139-159 243-263 271-291 305-325 454-474
- Cellular Location
- Cell junction
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q27218 UniProtKB Entry Name ACH7_CAEEL NCBI Gene ID 178269 - General References
- Fleming JT, Squire MD, Barnes TM, Tornoe C, Matsuda K, Ahnn J, Fire A, Sulston JE, Barnard EA, Sattelle DB, Lewis JA: Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J Neurosci. 1997 Aug 1;17(15):5843-57. [Article]
- Authors unspecified: Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. [Article]
- Kaji H, Kamiie J, Kawakami H, Kido K, Yamauchi Y, Shinkawa T, Taoka M, Takahashi N, Isobe T: Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol Cell Proteomics. 2007 Dec;6(12):2100-9. Epub 2007 Aug 30. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Levamisole approved, investigational, vet_approved, withdrawn unknown target activator Details