Thioredoxin
Details
- Name
- Thioredoxin
- Kind
- protein
- Synonyms
- ADF
- ATL-derived factor
- SASP
- Surface-associated sulphydryl protein
- TRDX
- TRX
- TRX1
- Gene Name
- TXN
- UniProtKB Entry
- P10599Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008733|Thioredoxin MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
- Number of residues
- 105
- Molecular Weight
- 11737.42
- Theoretical pI
- Not Available
- GO Classification
- Functionsprotein homodimerization activity / protein-disulfide reductase (NAD(P)H) activity / protein-disulfide reductase activity / RNA binding / thioredoxin-disulfide reductase (NADPH) activityProcessescellular detoxification of hydrogen peroxide / negative regulation of transcription by RNA polymerase II / positive regulation of peptidyl-cysteine S-nitrosylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / response to nitric oxideComponentsextracellular region
- General Function
- Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:11118054, PubMed:9108029)
- Specific Function
- protein homodimerization activity
- Pfam Domain Function
- Thioredoxin (PF00085)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0017575|Thioredoxin (TXN) ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGAT AAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCT TTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTT AAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACC ATTAATGAATTAGTCTAA
- Chromosome Location
- 9
- Locus
- 9q31.3
- External Identifiers
Resource Link UniProtKB ID P10599 UniProtKB Entry Name THIO_HUMAN GeneCard ID TXN HGNC ID HGNC:12435 PDB ID(s) 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1M7T, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK, 2IFQ, 2IIY, 3E3E, 3KD0, 3M9J, 3M9K, 3QFA, 3QFB, 3TRX, 4LL1, 4LL4, 4OO4, 4OO5, 4POK, 4POL, 4POM, 4PUF, 4TRX, 5DQY KEGG ID hsa:7295 NCBI Gene ID 7295 - General References
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