Thioredoxin

BE0004965ProteinHumansTXN

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). It is acted on by 3 drugs in DrugBank.

Gene name
TXN
UniProtKB entry
P10599Swiss-Prot
Cellular location
Nucleus
Residues / weight
105 residues · 11,737 Da
Also known as
ADF · ATL-derived factor · SASP · Surface-associated sulphydryl protein · TRDX

Resolves to

Protein
UniProtP10599UniProt nameTHIO_HUMAN
Gene
HGNCHGNC:12435NCBI Gene7295GeneCardsTXN
Pharmacology
KEGGhsa:7295
Structure
PDB1AIUPDB1AUCPDB1CQG
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thioredoxin, and which indications are they being tested in?

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