Histone H1.4

BE0005131ProteinHumansH1-4

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:35581345, PubMed:40240600). It is acted on by 1 drug in DrugBank.

Gene name
H1-4
UniProtKB entry
P10412Swiss-Prot
Cellular location
Nucleus
Residues / weight
219 residues · 21,865 Da
Also known as
H1F4 · HIST1H1E · Histone H1b · Histone H1s-4

Resolves to

Protein
UniProtP10412UniProt nameH14_HUMAN
Gene
HGNCHGNC:4718NCBI Gene3008GeneCardsH1-4
Pharmacology
KEGGhsa:3008
Structure
PDB3TZDPDB5JJZPDB6H8P
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone H1.4, how selective are they, and which programs against it are still in active trials?

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