Inward rectifier potassium channel 4

BE0005187ProteinHumansKCNJ4

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. It is acted on by 1 drug in DrugBank.

Gene name
KCNJ4
UniProtKB entry
P48050Swiss-Prot
Cellular location
Cell membrane
Residues / weight
445 residues · 49,500 Da
Also known as
Hippocampal inward rectifier · HIR · HIRK2 · HRK1 · Inward rectifier K(+) channel Kir2.3

Resolves to

Protein
UniProtP48050UniProt nameKCNJ4_HUMAN
Gene
HGNCHGNC:6265NCBI Gene3761GeneCardsKCNJ4
Pharmacology
IUPHAR/GtoPdb432KEGGhsa:3761
Structure
PDB3GJ9
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inward rectifier potassium channel 4, how selective are they, and which programs against it are still in active trials?

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