Cyclic nucleotide-gated channel alpha-1

BE0005300ProteinHumansCNGA1

Pore-forming subunit of the rod cyclic nucleotide-gated channel. It is acted on by 2 drugs in DrugBank.

Gene name
CNGA1
UniProtKB entry
P29973Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
686 residues · 79,125 Da
Also known as
cGMP-gated cation channel alpha-1 · CNCG · CNCG1 · CNG channel alpha-1 · CNG-1

Resolves to

Protein
UniProtP29973UniProt nameCNGA1_HUMAN
Gene
HGNCHGNC:2148NCBI Gene1259GeneCardsCNGA1
Pharmacology
IUPHAR/GtoPdb394KEGGhsa:1259
Structure
PDB7LFTPDB7LFWPDB7LFX
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclic nucleotide-gated channel alpha-1, how selective are they, and which programs against it are still in active trials?

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