Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

BE0005530ProteinHumansPTEN

Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). It is acted on by 2 drugs in DrugBank.

Gene name
PTEN
UniProtKB entry
P60484Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
403 residues · 47,166 Da
Also known as
3.1.3.16 · 3.1.3.48 · 3.1.3.67 · Inositol polyphosphate 3-phosphatase · MMAC1

Resolves to

Protein
UniProtP60484UniProt namePTEN_HUMAN
Gene
HGNCHGNC:9588NCBI Gene5728GeneCardsPTEN
Pharmacology
IUPHAR/GtoPdb2497KEGGhsa:5728
Structure
PDB1D5RPDB2KYLPDB4O1V
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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71Clinical trialsTrials of drugs acting on it, by phase and status
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27GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, and which indications are they being tested in?

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