G protein-coupled receptor 35

BE0005562ProteinHumansGPR35

G protein-coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling... It is acted on by 5 drugs in DrugBank.

Gene name
GPR35
UniProtKB entry
Q9HC97Swiss-Prot
Cellular location
Cell membrane
Residues / weight
309 residues · 34,072 Da
Also known as
KYNA receptor · Kynurenic acid receptor

Resolves to

Protein
UniProtQ9HC97UniProt nameGPR35_HUMAN
Gene
HGNCHGNC:4492NCBI Gene2859GeneCardsGPR35
Pharmacology
IUPHAR/GtoPdb102KEGGhsa:2859
Structure
PDB8H8J
Drugs

What you can answer from here — as of June 19, 2026

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G protein-coupled receptor 35, how selective are they, and which programs against it are still in active trials?

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