Ubiquitin carboxyl-terminal hydrolase isozyme L1

BE0005767ProteinHumansUCHL1

Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis (PubMed:22212137, PubMed:23359680). It is acted on by 1 drug in DrugBank.

Gene name
UCHL1
UniProtKB entry
P09936Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
223 residues · 24,824 Da
Also known as
3.4.19.12 · Neuron cytoplasmic protein 9.5 · PGP 9.5 · PGP9.5 · Ubiquitin thioesterase L1

Resolves to

Protein
UniProtP09936UniProt nameUCHL1_HUMAN
Gene
HGNCHGNC:12513NCBI Gene7345GeneCardsUCHL1
Pharmacology
IUPHAR/GtoPdb2426KEGGhsa:7345
Structure
PDB2ETLPDB2LENPDB3IFW
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin carboxyl-terminal hydrolase isozyme L1, and which indications are they being tested in?

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