P2X purinoceptor 4

BE0005793ProteinHumansP2RX4

ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). It is acted on by 4 drugs in DrugBank.

Gene name
P2RX4
UniProtKB entry
Q99571Swiss-Prot
Cellular location
Cell membrane
Residues / weight
388 residues · 43,369 Da
Also known as
ATP receptor · P2X4 · Purinergic receptor

Resolves to

Protein
UniProtQ99571UniProt nameP2RX4_HUMAN
Gene
HGNCHGNC:8535NCBI Gene5025GeneCardsP2RX4
Pharmacology
IUPHAR/GtoPdb481KEGGhsa:5025
Structure
PDB9BQHPDB9BQIPDB9C48
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on P2X purinoceptor 4, how selective are they, and which programs against it are still in active trials?

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