Protein PML

BE0005808ProteinHumansPML

Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. It is acted on by 1 drug in DrugBank.

Gene name
PML
UniProtKB entry
P29590Swiss-Prot
Cellular location
Nucleus
Residues / weight
882 residues · 97,549 Da
Also known as
E3 SUMO-protein ligase PML · MYL · PP8675 · Promyelocytic leukemia protein · RING finger protein 71

Resolves to

Protein
UniProtP29590UniProt namePML_HUMAN
Gene
HGNCHGNC:9113NCBI Gene5371GeneCardsPML
Pharmacology
KEGGhsa:5371
Structure
PDB1BORPDB2MVWPDB2MWX
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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97+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein PML, how selective are they, and which programs against it are still in active trials?

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