Protein O-GlcNAcase

BE0005827ProteinHumansOGA

Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). It is acted on by 4 drugs in DrugBank.

Gene name
OGA
UniProtKB entry
O60502Swiss-Prot
Cellular location
Nucleus
Residues / weight
916 residues · 102,914 Da
Also known as
3.2.1.169 · Beta-hexosaminidase · Beta-N-acetylglucosaminidase · Beta-N-acetylhexosaminidase · HEXC

Resolves to

Protein
UniProtO60502UniProt nameOGA_HUMAN
Gene
HGNCHGNC:7056NCBI Gene10724GeneCardsOGA
Pharmacology
IUPHAR/GtoPdb3101KEGGhsa:10724
Structure
PDB2YDQPDB5M7RPDB5M7S
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
26+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Protein O-GlcNAcase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In