DNA gyrase subunit A

BE0008382ProteinEscherichia coli (strain K12)gyrA

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:12051842, PubMed:18642932, PubMed:186775, PubMed:19060136, PubMed:19965760, PubMed:20356737, PubMed:22457353, PubMed:23294697, PubMed:3031051, PubMed:7811004, PubMed:9148951). It is acted on by 15 drugs in DrugBank.

Gene name
gyrA
UniProtKB entry
P0AES4Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
875 residues · 96,963 Da
Also known as
5.6.2.2 · 5.99.1.3 · hisW · nalA · parD

Resolves to

Protein
UniProtP0AES4UniProt nameGYRA_ECOLI
Gene
NCBI Gene946614
Pharmacology
KEGGecj:JW2225
Structure
PDB1AB4PDB1X75PDB1ZI0
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit A, how selective are they, and which programs against it are still in active trials?

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