Lysosomal protective protein

BE0008657ProteinHumansCTSA

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity (PubMed:1907282). It is acted on by 4 drugs in DrugBank.

Gene name
CTSA
UniProtKB entry
P10619Swiss-Prot
Cellular location
Lysosome
Residues / weight
480 residues · 54,466 Da
Also known as
3.4.16.5 · Carboxypeptidase C · Carboxypeptidase L · Cathepsin A · PPCA

Resolves to

Protein
UniProtP10619UniProt namePPGB_HUMAN
Gene
HGNCHGNC:9251NCBI Gene5476GeneCardsCTSA
Pharmacology
IUPHAR/GtoPdb1581KEGGhsa:5476
Structure
PDB1IVYPDB3BP4PDB3BP7
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysosomal protective protein, how selective are they, and which programs against it are still in active trials?

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