Hydroxyacid-oxoacid transhydrogenase, mitochondrial

BE0008675ProteinHumansADHFE1

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). It is acted on by 1 drug in DrugBank.

Gene name
ADHFE1
UniProtKB entry
Q8IWW8Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
467 residues · 50,307 Da
Also known as
1.1.99.24 · ADHFe1 · Alcohol dehydrogenase iron-containing protein 1 · Fe-containing alcohol dehydrogenase · HOT

Resolves to

Protein
UniProtQ8IWW8UniProt nameHOT_HUMAN
Gene
HGNCHGNC:16354NCBI Gene137872GeneCardsADHFE1
Pharmacology
KEGGhsa:137872
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hydroxyacid-oxoacid transhydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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