Cytochrome c oxidase copper chaperone

BE0008686ProteinHumansCOX17

Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:15229189, PubMed:19393246, PubMed:31903891, PubMed:35750769). It is acted on by 1 drug in DrugBank.

Gene name
COX17
UniProtKB entry
Q14061Swiss-Prot
Cellular location
Mitochondrion intermembrane space
Residues / weight
63 residues · 6,915 Da

Resolves to

Protein
UniProtQ14061UniProt nameCOX17_HUMAN
Gene
HGNCHGNC:2264NCBI Gene10063GeneCardsCOX17
Pharmacology
KEGGhsa:10063
Structure
PDB2L0YPDB2LGQPDB2RN9
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome c oxidase copper chaperone, how selective are they, and which programs against it are still in active trials?

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