Cell growth-regulating nucleolar protein

Details

Name
Cell growth-regulating nucleolar protein
Kind
protein
Synonyms
  • MLZ-264
  • Protein expressed in male leptotene and zygotene spermatocytes 264
Gene Name
Lyar
UniProtKB Entry
Q08288Swiss-Prot
Organism
Mouse
NCBI Taxonomy ID
10090
Amino acid sequence
>lcl|BSEQ0049632|Cell growth-regulating nucleolar protein
MVFFTCNACGESVKKIQVEKHVSNCRNCECLSCIDCGKDFWGDDYKSHVKCISEGQKYGG
KGYEAKTHKGDAKQQAWIQKINELIKKPNVSPKVRELLQQISAFDNVPRKKAKFQNWMKN
SLKVHSDSVLEQVWDIFSEASSSEQDQQQPPSHTAKPHAEMPITKVPSAKTNGTTEEQTE
AKKNKRERKEERQKNRKKEKKELKLENHQENLRGQKPKKRKKNQEAGHEAAGEEAAEASG
PPEKKKAQGGQASEEGADRNGGPGEDAAEGQTKTAAGKRKRPKHSGAESGYKKKKMKLPE
QPEEGEAKDHEAPSKGKFNWKGTIKAVLKQAPDNEISVKKLKKKVIAQYHAVMNDHHTSE
EELLAIFNRKISRNPTFKVLKDRVKLLK
Number of residues
388
Molecular Weight
43735.435
Theoretical pI
Not Available
GO Classification
Functions
metal ion binding / RNA binding
Components
nucleolus / nucleus
General Function
Not Available
Specific Function
Metal ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049633|Cell growth-regulating nucleolar protein (Lyar)
ATGGTATTTTTTACATGCAATGCATGTGGTGAATCCGTGAAGAAAATACAAGTGGAAAAG
CATGTGTCTAACTGCAGAAACTGTGAATGTCTTTCCTGCATTGACTGTGGGAAAGATTTC
TGGGGTGATGACTACAAAAGCCATGTGAAGTGCATCAGTGAAGGTCAGAAGTACGGAGGC
AAAGGCTATGAAGCCAAGACACACAAAGGTGATGCAAAACAGCAGGCATGGATTCAGAAA
ATTAATGAGTTAATAAAGAAACCCAACGTCAGCCCCAAGGTGCGAGAACTTTTGCAGCAA
ATCAGTGCTTTTGATAATGTTCCCAGAAAAAAGGCGAAGTTTCAGAACTGGATGAAAAAC
AGCCTGAAAGTGCACAGCGACTCCGTTCTAGAGCAGGTGTGGGATATCTTCTCCGAAGCA
TCCAGCAGTGAGCAAGATCAGCAGCAGCCACCCAGCCACACGGCCAAGCCACATGCAGAG
ATGCCGATCACTAAAGTTCCATCTGCAAAAACAAATGGCACCACAGAAGAGCAAACCGAG
GCGAAGAAGAATAAAAGAGAAAGGAAGGAGGAACGGCAGAAAAACAGGAAGAAAGAGAAG
AAAGAGCTGAAGCTAGAAAACCACCAGGAAAACCTGAGGGGCCAGAAGCCAAAGAAGCGC
AAGAAGAACCAGGAGGCCGGACATGAGGCTGCTGGGGAGGAGGCCGCCGAGGCCAGCGGC
CCACCGGAGAAGAAGAAAGCCCAGGGAGGACAGGCTTCTGAAGAGGGAGCAGACAGAAAT
GGGGGCCCTGGGGAGGATGCTGCCGAGGGGCAGACCAAGACAGCAGCAGGGAAACGGAAG
CGGCCAAAGCACTCAGGAGCTGAGTCTGGTTACAAGAAAAAAAAGATGAAGTTACCAGAG
CAGCCTGAAGAGGGAGAGGCCAAGGACCACGAGGCTCCATCGAAAGGTAAATTCAACTGG
AAGGGGACCATTAAGGCTGTTTTGAAACAGGCTCCAGACAACGAGATATCAGTCAAGAAG
TTAAAGAAAAAGGTTATAGCTCAGTACCATGCGGTGATGAACGACCATCACACATCGGAG
GAGGAGCTCCTGGCCATCTTCAACAGGAAGATCAGCAGGAACCCCACCTTTAAGGTGCTG
AAGGACAGAGTAAAGCTTCTGAAGTGA
Chromosome Location
5
Locus
5 20.29 cM
External Identifiers
ResourceLink
UniProtKB IDQ08288
UniProtKB Entry NameLYAR_MOUSE
PDB ID(s)1WJV
KEGG IDmmu:17089
NCBI Gene ID17089
General References
  1. Su L, Hershberger RJ, Weissman IL: LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Genes Dev. 1993 May;7(5):735-48. [Article]
  2. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [Article]
  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]
  4. Kogo H, Kowa-Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T, Inagaki H, Taniguchi M, Toda T, Kurahashi H: Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans. J Hum Genet. 2010 May;55(5):293-9. doi: 10.1038/jhg.2010.26. Epub 2010 Mar 26. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Copperapproved, investigationalunknowntargetDetails