Small ribosomal subunit protein uS5

Details

Name
Small ribosomal subunit protein uS5
Kind
protein
Synonyms
  • 40S ribosomal protein S2
  • 40S ribosomal protein S4
  • Protein LLRep3
  • RPS4
Gene Name
RPS2
UniProtKB Entry
P15880Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049634|Small ribosomal subunit protein uS5
MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEW
MPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQ
RTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTV
PCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKAT
FDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT
Number of residues
293
Molecular Weight
31324.22
Theoretical pI
Not Available
GO Classification
Processes
cytoplasmic translation / positive regulation of ubiquitin-protein transferase activity
Components
cytoplasm / cytosolic ribosome
General Function
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)
Specific Function
Cadherin binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0049635|40S ribosomal protein S2 (RPS2)
ATGGCGGATGACGCCGGTGCAGCGGGGGGGCCCGGGGGCCCTGGTGGCCCTGGGATGGGG
AACCGCGGTGGCTTCCGCGGAGGTTTCGGCAGTGGCATCCGGGGCCGGGGTCGCGGCCGT
GGACGGGGCCGGGGCCGAGGCCGCGGAGCTCGCGGAGGCAAGGCCGAGGATAAGGAGTGG
ATGCCCGTCACCAAGTTGGGCCGCTTGGTCAAGGACATGAAGATCAAGTCCCTGGAGGAG
ATCTATCTCTTCTCCCTGCCTATTAAGGAATCAGAGATCATTGATTTCTTCCTGGGGGCC
TCTCTCAAGGATGAGGTTTTGAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAG
CGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTCGGTCTGGGT
GTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTC
TCCATCGTCCCCGTGCGCAGAGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTC
CCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCCTGCACCCAGG
GGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGAT
GACTGCTACACCTCAGCCCGGGGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACC
TTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAGGAGACTGTA
TTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTC
TCCGTGCAGCGGACTCAGGCTCCAGCTGTGGCTACAACATAG
Chromosome Location
16
Locus
16p13.3
External Identifiers
ResourceLink
UniProtKB IDP15880
UniProtKB Entry NameRS2_HUMAN
GeneCard IDRPS2
HGNC IDHGNC:10404
PDB ID(s)4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6G18, 6G4S, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBD, 6YBW, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOK, 6ZON, 6ZP4, 6ZUO, 6ZV6, 6ZVH, 6ZVJ, 6ZXD, 6ZXE, 6ZXF, 6ZXG, 6ZXH, 7A09, 7JQB, 7JQC, 7K5I, 7QP6, 7QP7, 7QVP, 7R4X, 7TQL, 7WTV, 7WTW, 7WTX, 7WTZ, 7WU0, 7XNX, 7XNY, 8G5Y, 8G5Z, 8G60, 8G61, 8G6J, 8GLP, 8IFD, 8IFE, 8JDJ, 8JDK, 8JDL, 8JDM, 8OZ0, 8PPK, 8PPL, 8T4S, 8Y0W, 8Y0X
KEGG IDhsa:6187
NCBI Gene ID6187
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Copperapproved, investigationalunknowntargetDetails