Heterogeneous nuclear ribonucleoprotein L

Details

Name
Heterogeneous nuclear ribonucleoprotein L
Kind
protein
Synonyms
  • hnRNP L
  • HNRPL
Gene Name
HNRNPL
UniProtKB Entry
P14866Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049644|Heterogeneous nuclear ribonucleoprotein L
MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKR
LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVE
ALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKIS
RPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDS
VQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNP
NKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYG
PQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPG
AAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSES
RNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSE
RSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
Number of residues
589
Molecular Weight
64132.45
Theoretical pI
Not Available
GO Classification
Functions
mRNA binding / transcription cis-regulatory region binding
Processes
mRNA processing / negative regulation of DNA-templated transcription / regulation of RNA splicing
Components
chromatin / cytoplasm / ribonucleoprotein complex
General Function
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8
Specific Function
Mrna binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus, nucleoplasm
Gene sequence
>lcl|BSEQ0049645|Heterogeneous nuclear ribonucleoprotein L (HNRNPL)
ATGTCGCGGAGGCTGCTGCCCCGGGCGGAGAAGCGGCGTCGGCGGCTGGAGCAGAGGCAG
CAGCCGGACGAGCAGCGGAGGCGGTCGGGAGCGATGGTGAAGATGGCGGCGGCGGGCGGC
GGAGGCGGCGGTGGCCGCTACTACGGCGGCGGCAGTGAGGGCGGCCGGGCCCCTAAGCGG
CTCAAGACTGACAACGCCGGCGACCAGCACGGAGGCGGCGGCGGTGGCGGTGGAGGAGCC
GGGGCGGCGGGCGGCGGCGGCGGTGGGGAGAACTACGATGACCCGCACAAAACCCCTGCC
TCCCCAGTTGTCCACATCAGGGGCCTGATTGACGGTGTGGTGGAAGCAGACCTTGTGGAG
GCCTTGCAGGAGTTTGGACCCATCAGCTATGTGGTGGTAATGCCTAAAAAGAGACAAGCA
CTGGTGGAGTTTGAAGATGTGTTGGGGGCTTGCAACGCAGTGAACTACGCAGCCGACAAC
CAAATATACATTGCTGGTCACCCAGCTTTTGTCAACTACTCTACCAGCCAGAAGATCTCC
CGCCCTGGGGACTCGGATGACTCCCGGAGCGTGAACAGTGTGCTTCTCTTTACCATCCTG
AACCCCATTTATTCGATCACCACGGATGTTCTTTACACTATCTGTAATCCTTGTGGCCCT
GTCCAGAGAATTGTCATTTTCAGGAAGAATGGAGTTCAGGCGATGGTGGAATTTGACTCA
GTTCAAAGTGCCCAGCGGGCCAAGGCCTCTCTCAATGGGGCTGATATCTATTCTGGCTGT
TGCACTCTGAAGATCGAATACGCAAAGCCTACACGCTTGAATGTGTTCAAGAATGATCAG
GATACTTGGGACTACACAAACCCCAATCTCAGTGGACAAGGTGACCCTGGCAGCAACCCC
AACAAACGCCAGAGGCAGCCCCCTCTCCTGGGAGATCACCCCGCAGAATATGGAGGGCCC
CACGGTGGGTACCACAGCCATTACCATGATGAGGGCTACGGGCCCCCCCCACCTCACTAC
GAAGGGAGAAGGATGGGTCCACCAGTGGGGGGTCACCGTCGGGGCCCAAGTCGCTACGGC
CCCCAGTATGGGCACCCCCCACCCCCTCCCCCACCACCCGAGTATGGCCCTCACGCCGAC
AGCCCTGTGCTCATGGTCTATGGCTTGGATCAATCTAAGATGAACTGTGACCGAGTCTTC
AATGTCTTCTGCTTATATGGCAATGTGGAGAAGGTGAAATTCATGAAAAGCAAGCCGGGG
GCCGCCATGGTGGAGATGGCTGATGGCTACGCTGTAGACCGGGCCATTACCCACCTCAAC
AACAACTTCATGTTTGGGCAGAAGCTGAATGTCTGTGTCTCCAAGCAGCCAGCCATCATG
CCTGGTCAGTCATACGGGTTGGAAGACGGGTCTTGCAGTTACAAAGACTTCAGTGAATCC
CGGAACAATCGGTTCTCCACCCCAGAGCAGGCAGCCAAGAACCGCATCCAGCACCCCAGC
AACGTGCTGCACTTCTTCAACGCCCCGCTGGAGGTGACCGAGGAGAACTTCTTTGAGATC
TGCGATGAGCTGGGAGTGAAGCGGCCATCTTCTGTGAAAGTATTCTCAGGCAAAAGTGAG
CGCAGCTCCTCTGGACTGCTGGAGTGGGAATCCAAGAGCGATGCCCTGGAGACTCTGGGC
TTCCTGAACCATTACCAGATGAAAAACCCAAATGGTCCATACCCTTACACTCTGAAGTTG
TGTTTCTCCACTGCTCAGCACGCCTCCTAA
Chromosome Location
19
Locus
19q13.2
External Identifiers
ResourceLink
UniProtKB IDP14866
UniProtKB Entry NameHNRPL_HUMAN
GeneCard IDHNRNPL
HGNC IDHGNC:5045
PDB ID(s)3R27, 3TO8, 7EVR
KEGG IDhsa:3191
NCBI Gene ID3191
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Copperapproved, investigationalunknowntargetDetails