Splicing factor 3A subunit 2

BE0008966ProteinHumansSF3A2

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). It is acted on by 1 drug in DrugBank.

Gene name
SF3A2
UniProtKB entry
Q15428Swiss-Prot
Cellular location
Nucleus
Residues / weight
464 residues · 49,255 Da
Also known as
SAP 62 · SAP62 · SF3a66 · Spliceosome-associated protein 62

Resolves to

Protein
UniProtQ15428UniProt nameSF3A2_HUMAN
Gene
HGNCHGNC:10766NCBI Gene8175GeneCardsSF3A2
Pharmacology
KEGGhsa:8175
Structure
PDB5Z56PDB5Z57PDB5Z58
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Splicing factor 3A subunit 2, how selective are they, and which programs against it are still in active trials?

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