Eukaryotic translation initiation factor 6

BE0008972ProteinHumansEIF6

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). It is acted on by 1 drug in DrugBank.

Gene name
EIF6
UniProtKB entry
P56537Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
245 residues · 26,599 Da
Also known as
B(2)GCN homolog · B4 integrin interactor · CAB · eIF-6 · EIF3A

Resolves to

Protein
UniProtP56537UniProt nameIF6_HUMAN
Gene
HGNCHGNC:6159NCBI Gene3692GeneCardsEIF6
Pharmacology
KEGGhsa:3692
Structure
PDB6LQMPDB6LSRPDB6LSS
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Eukaryotic translation initiation factor 6, how selective are they, and which programs against it are still in active trials?

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