Eukaryotic initiation factor 4A-I

BE0008973ProteinHumansEIF4A1

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). It is acted on by 2 drugs in DrugBank.

Gene name
EIF4A1
UniProtKB entry
P60842Swiss-Prot
Cellular location
Cytoplasm, perinuclear region
Residues / weight
406 residues · 46,154 Da
Also known as
3.6.4.13 · ATP-dependent RNA helicase eIF4A-1 · DDX2A · eIF-4A-I · EIF4A

Resolves to

Protein
UniProtP60842UniProt nameIF4A1_HUMAN
Gene
HGNCHGNC:3282NCBI Gene1973GeneCardsEIF4A1
Pharmacology
KEGGhsa:1973
Structure
PDB2G9NPDB2ZU6PDB3EIQ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Eukaryotic initiation factor 4A-I, how selective are they, and which programs against it are still in active trials?

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