14-3-3 protein beta/alpha

BE0008974ProteinHumansYWHAB

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. It is acted on by 2 drugs in DrugBank.

Gene name
YWHAB
UniProtKB entry
P31946Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
246 residues · 28,082 Da
Also known as
KCIP-1 · Protein 1054 · Protein kinase C inhibitor protein 1

Resolves to

Protein
UniProtP31946UniProt name1433B_HUMAN
Gene
HGNCHGNC:12849NCBI Gene7529GeneCardsYWHAB
Pharmacology
KEGGhsa:7529
Structure
PDB2BQ0PDB2C23PDB4DNK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 14-3-3 protein beta/alpha, how selective are they, and which programs against it are still in active trials?

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