Hepatoma-derived growth factor
Details
- Name
- Hepatoma-derived growth factor
- Kind
- protein
- Synonyms
- HDGF
- High mobility group protein 1-like 2
- HMG-1L2
- HMG1L2
- Gene Name
- HDGF
- UniProtKB Entry
- P51858Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049665|Hepatoma-derived growth factor MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGP KDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAE GDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEK EAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL
- Number of residues
- 240
- Molecular Weight
- 26788.105
- Theoretical pI
- Not Available
- GO Classification
- Functionsactin binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / transcription corepressor activity / tubulin bindingProcesseschromatin remodeling / negative regulation of transcription by RNA polymerase II / positive regulation of cell division / positive regulation of transcription by RNA polymerase II / protein localization to nucleusComponentscollagen-containing extracellular matrix / extracellular region / nucleus / transcription repressor complex
- General Function
- Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618)
- Specific Function
- actin binding
- Pfam Domain Function
- PWWP (PF00855)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049666|Hepatoma-derived growth factor (HDGF) ATGTCGCGATCCAACCGGCAGAAGGAGTACAAATGCGGGGACCTGGTGTTCGCCAAGATG AAGGGCTACCCACACTGGCCGGCCCGGATTGACGAGATGCCTGAGGCTGCCGTGAAATCA ACAGCCAACAAATACCAAGTCTTTTTTTTCGGGACCCACGAGACGGCATTCCTGGGCCCC AAAGACCTCTTCCCTTACGAGGAATCCAAGGAGAAGTTTGGCAAGCCCAACAAGAGGAAA GGGTTCAGCGAGGGGCTGTGGGAGATCGAGAACAACCCTACTGTCAAGGCTTCCGGCTAT CAGTCCTCCCAGAAAAAGAGCTGTGTGGAAGAGCCTGAACCAGAGCCCGAAGCTGCAGAG GGTGACGGTGATAAGAAGGGGAATGCAGAGGGCAGCAGCGACGAGGAAGGGAAGCTGGTC ATTGATGAGCCAGCCAAGGAGAAGAACGAGAAAGGAGCGTTGAAGAGGAGAGCAGGGGAC TTGCTGGAGGACTCTCCTAAACGTCCCAAGGAGGCAGAAAACCCTGAAGGAGAGGAGAAG GAGGCAGCCACCTTGGAGGTTGAGAGGCCCCTTCCTATGGAGGTGGAAAAGAATAGCACC CCCTCTGAGCCCGGCTCTGGCCGGGGGCCTCCCCAAGAGGAAGAAGAAGAGGAGGATGAA GAGGAAGAGGCTACCAAGGAAGATGCTGAGGCCCCAGGCATCAGAGATCATGAGAGCCTG TAG
- Chromosome Location
- 1
- Locus
- 1q23.1
- External Identifiers
Resource Link UniProtKB ID P51858 UniProtKB Entry Name HDGF_HUMAN GeneCard ID HDGF HGNC ID HGNC:4856 PDB ID(s) 1RI0, 2NLU KEGG ID hsa:3068 NCBI Gene ID 3068 - General References
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