Proteinase-activated receptor 4
Details
- Name
- Proteinase-activated receptor 4
- Kind
- protein
- Synonyms
- Coagulation factor II receptor-like 3
- PAR-4
- PAR4
- Thrombin receptor-like 3
- Gene Name
- F2RL3
- UniProtKB Entry
- Q96RI0Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049687|Proteinase-activated receptor 4 MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP GDTVASKASAEGGSRGMGTHSSLLQ
- Number of residues
- 385
- Molecular Weight
- 41132.43
- Theoretical pI
- Not Available
- GO Classification
- FunctionsG protein-coupled receptor activity / protease bindingProcessesphospholipase C-activating G protein-coupled receptor signaling pathway / platelet aggregation
- General Function
- Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109)
- Specific Function
- G protein-coupled receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- 1-17
- Transmembrane Regions
- 83-103 109-129 152-172 193-213 248-268 284-304 320-343
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0049688|Proteinase-activated receptor 4 (F2RL3) ATGTGGGGGCGACTGCTCCTGTGGCCCCTGGTGCTGGGGTTCAGCCTGTCTGGCGGCACC CAGACCCCCAGCGTCTACGACGAGAGCGGGAGCACCGGAGGTGGTGATGACAGCACGCCC TCAATCCTGCCTGCCCCCCGCGGCTACCCAGGCCAAGTCTGTGCCAATGACAGTGACACC CTGGAGCTCCCGGACAGCTCACGGGCACTGCTTCTGGGCTGGGTGCCCACCAGGCTGGTG CCCGCCCTCTATGGGCTGGTCCTGGTGGTGGGGCTGCCGGCCAATGGGCTGGCGCTGTGG GTGCTGGCCACGCAGGCACCTCGGCTGCCCTCCACCATGCTGCTGATGAACCTCGCGGCT GCTGACCTCCTGCTGGCCCTGGCGCTGCCCCCGCGGATCGCCTACCACCTGCGTGGCCAG CGCTGGCCCTTCGGGGAGGCCGCCTGCCGCCTGGCCACGGCCGCACTCTATGGTCACATG TATGGCTCAGTGCTGCTGCTGGCCGCCGTCAGCCTGGATCGCTACCTGGCCCTGGTGCAC CCGCTGCGGGCCCGCGCCCTGCGTGGCCGGCGCCTGGCCCTTGGACTCTGCATGGCTGCT TGGCTCATGGCGGCCGCCCTGGCACTGCCCCTGACACTGCAGCGGCAGACCTTCCGGCTG GCGCGCTCCGATCGCGTGCTCTGCCATGACGCGCTGCCCCTGGACGCACAGGCCTCCCAC TGGCAACCGGCCTTCACCTGCCTGGCGCTGTTGGGCTGTTTCCTGCCCCTGCTGGCCATG CTGCTGTGCTACGGGGCCACCCTGCACACGCTGGCGGCCAGCGGCCGGCGCTACGGCCAC GCGCTGAGGCTGACCGCAGTGGTGCTGGCCTCCGCCGTGGCCTTCTTCGTGCCCAGCAAC CTGCTGCTGCTGCTGCATTACTCGGACCCGAGCCCCAGCGCCTGGGGCAACCTCTATGGT GCCTACGTGCCCAGCCTGGCGCTGAGCACCCTCAACAGCTGCGTGGATCCCTTCATCTAC TACTACGTGTCGGCCGAGTTCAGGGACAAGGTGCGGGCAGGGCTCTTCCAACGGTCGCCG GGGGACACCGTGGCCTCCAAGGCCTCTGCGGAAGGGGGCAGCCGGGGCATGGGCACCCAC TCCTCTTTGCTCCAGTGA
- Chromosome Location
- 19
- Locus
- 19p13.11
- External Identifiers
Resource Link UniProtKB ID Q96RI0 UniProtKB Entry Name PAR4_HUMAN GeneCard ID F2RL3 HGNC ID HGNC:3540 PDB ID(s) 2ZPK, 3QDZ KEGG ID hsa:9002 IUPHAR/Guide To Pharmacology ID 350 NCBI Gene ID 9002 - General References
- Kahn ML, Hammes SR, Botka C, Coughlin SR: Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J Biol Chem. 1998 Sep 4;273(36):23290-6. [Article]
- Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR: A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13;394(6694):690-4. [Article]
- Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC: Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6642-6. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR: Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. [Article]