Proteinase-activated receptor 4

BE0008986ProteinHumansF2RL3

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). It is acted on by 2 drugs in DrugBank.

Gene name
F2RL3
UniProtKB entry
Q96RI0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
385 residues · 41,132 Da
Also known as
Coagulation factor II receptor-like 3 · PAR-4 · PAR4 · Thrombin receptor-like 3

Resolves to

Protein
UniProtQ96RI0UniProt namePAR4_HUMAN
Gene
HGNCHGNC:3540NCBI Gene9002GeneCardsF2RL3
Pharmacology
IUPHAR/GtoPdb350KEGGhsa:9002
Structure
PDB2ZPKPDB3QDZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
12+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Proteinase-activated receptor 4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In