Protein RIC-3

BE0009005ProteinHumansRIC3

Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458). It is acted on by 1 drug in DrugBank.

Gene name
RIC3
UniProtKB entry
Q7Z5B4Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
369 residues · 41,092 Da
Also known as
Resistant to inhibitor of cholinesterase 3

Resolves to

Protein
UniProtQ7Z5B4UniProt nameRIC3_HUMAN
Gene
HGNCHGNC:30338NCBI Gene79608GeneCardsRIC3
Pharmacology
KEGGhsa:79608
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein RIC-3, how selective are they, and which programs against it are still in active trials?

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