Prohibitin-2

BE0009007ProteinHumansPHB2

Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. It is acted on by 3 drugs in DrugBank.

Gene name
PHB2
UniProtKB entry
Q99623Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
299 residues · 33,296 Da
Also known as
B-cell receptor-associated protein BAP37 · BAP · D-prohibitin · REA · Repressor of estrogen receptor activity

Resolves to

Protein
UniProtQ99623UniProt namePHB2_HUMAN
Gene
HGNCHGNC:30306NCBI Gene11331GeneCardsPHB2
Pharmacology
KEGGhsa:11331
Structure
PDB6IQEPDB8J4IPDB8RRH
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prohibitin-2, how selective are they, and which programs against it are still in active trials?

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