Prohibitin-2

Details

Name
Prohibitin-2
Kind
protein
Synonyms
  • B-cell receptor-associated protein BAP37
  • BAP
  • D-prohibitin
  • REA
  • Repressor of estrogen receptor activity
Gene Name
PHB2
UniProtKB Entry
Q99623Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049728|Prohibitin-2
MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQ
DTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSM
YQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILD
DVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGE
ALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
Number of residues
299
Molecular Weight
33296.06
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / nuclear estrogen receptor binding / protein heterodimerization activity / protein homodimerization activity / sphingolipid binding
Processes
activation of protein kinase C activity / antiviral innate immune response / B cell activation / CD40 signaling pathway / cell migration / cellular response to hypoxia / cellular response to retinoic acid / estrogen receptor signaling pathway / mammary gland epithelial cell proliferation / mitophagy / negative regulation of DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / positive regulation of DNA-binding transcription factor activity / positive regulation of immunoglobulin production / positive regulation of non-canonical NF-kappaB signal transduction / protein import into nucleus / regulation of cardiolipin metabolic process / regulation of cytochrome-c oxidase activity / RIG-I signaling pathway
Components
axon / GABA-ergic synapse / glutamatergic synapse / mitochondrial prohibitin complex / plasma membrane / postsynaptic density / presynaptic active zone / protein-containing complex
General Function
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus
Specific Function
amide binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion inner membrane
Gene sequence
>lcl|BSEQ0049729|Prohibitin-2 (PHB2)
ATGGCCCAGAACTTGAAGGACTTGGCGGGACGGCTGCCCGCCGGGCCCCGGGGCATGGGC
ACGGCCCTGAAGCTGTTGCTGGGGGCCGGCGCCGTGGCCTACGGTGTGCGCGAATCTGTG
TTCACCGTGGAAGGCGGGCACAGAGCCATCTTCTTCAATCGGATCGGTGGAGTGCAGCAG
GACACTATCCTGGCCGAGGGCCTTCACTTCAGGATCCCTTGGTTCCAGTACCCCATTATC
TATGACATTCGGGCCAGACCTCGAAAAATCTCCTCCCCTACAGGCTCCAAAGACCTACAG
ATGGTGAATATCTCCCTGCGAGTGTTGTCTCGACCCAATGCTCAGGAGCTTCCTAGCATG
TACCAGCGCCTAGGGCTGGACTACGAGGAACGAGTGTTGCCGTCCATTGTCAACGAGGTG
CTCAAGAGTGTGGTGGCCAAGTTCAATGCCTCACAGCTGATCACCCAGCGGGCCCAGGTA
TCCCTGTTGATCCGCCGGGAGCTGACAGAGAGGGCCAAGGACTTCAGCCTCATCCTGGAT
GATGTGGCCATCACAGAGCTGAGCTTTAGCCGAGAGTACACAGCTGCTGTAGAAGCCAAA
CAAGTGGCCCAGCAGGAGGCCCAGCGGGCCCAATTCTTGGTAGAAAAAGCAAAGCAGGAA
CAGCGGCAGAAAATTGTGCAGGCCGAGGGTGAGGCCGAGGCTGCCAAGATGCTTGGAGAA
GCACTGAGCAAGAACCCTGGCTACATCAAACTTCGCAAGATTCGAGCAGCCCAGAATATC
TCCAAGACGATCGCCACATCACAGAATCGTATCTATCTCACAGCTGACAACCTTGTGCTG
AACCTACAGGATGAAAGTTTCACCAGGGGAAGTGACAGCCTCATCAAGGGTAAGAAATGA
Chromosome Location
12
Locus
12p13.31
External Identifiers
ResourceLink
UniProtKB IDQ99623
UniProtKB Entry NamePHB2_HUMAN
GeneCard IDPHB2
HGNC IDHGNC:30306
PDB ID(s)6IQE, 8J4I
KEGG IDhsa:11331
NCBI Gene ID11331
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
CapsaicinapprovedunknowntargetDetails
RocaglamideexperimentalyestargetinhibitorDetails
DidesmethylrocaglamideexperimentalyestargetinhibitorDetails