Lymphoid enhancer-binding factor 1

BE0009011ProteinHumansLEF1

Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). It is acted on by 1 drug in DrugBank.

Gene name
LEF1
UniProtKB entry
Q9UJU2Swiss-Prot
Cellular location
Nucleus
Residues / weight
399 residues · 44,200 Da
Also known as
LEF-1 · T cell-specific transcription factor 1-alpha · TCF1-alpha

Resolves to

Protein
UniProtQ9UJU2UniProt nameLEF1_HUMAN
Gene
HGNCHGNC:6551NCBI Gene51176GeneCardsLEF1
Pharmacology
KEGGhsa:51176
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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32GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lymphoid enhancer-binding factor 1, how selective are they, and which programs against it are still in active trials?

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