Diablo IAP-binding mitochondrial protein

BE0009023ProteinHumansDIABLO

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. It is acted on by 1 drug in DrugBank.

Gene name
DIABLO
UniProtKB entry
Q9NR28Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
239 residues · 27,131 Da
Also known as
Diablo homolog, mitochondrial · Direct IAP-binding protein with low pI · Second mitochondria-derived activator of caspases · SMAC

Resolves to

Protein
UniProtQ9NR28UniProt nameDBLOH_HUMAN
Gene
HGNCHGNC:21528NCBI Gene56616GeneCardsDIABLO
Pharmacology
KEGGhsa:56616
Structure
PDB1FEWPDB1G3FPDB1G73
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Diablo IAP-binding mitochondrial protein, and which indications are they being tested in?

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