Heat shock protein 105 kDa

BE0009029ProteinHumansHSPH1

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). It is acted on by 1 drug in DrugBank.

Gene name
HSPH1
UniProtKB entry
Q92598Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
858 residues · 96,864 Da
Also known as
Antigen NY-CO-25 · Heat shock 110 kDa protein · Heat shock protein family H member 1 · HSP105 · HSP110

Resolves to

Protein
UniProtQ92598UniProt nameHS105_HUMAN
Gene
HGNCHGNC:16969NCBI Gene10808GeneCardsHSPH1
Pharmacology
KEGGhsa:10808
Structure
PDB6GFA
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Heat shock protein 105 kDa, and which indications are they being tested in?

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