Pappalysin-1

BE0009031ProteinHumansPAPPA

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. It is acted on by 1 drug in DrugBank.

Gene name
PAPPA
UniProtKB entry
Q13219Swiss-Prot
Cellular location
Secreted
Residues / weight
1,627 residues · 180,971 Da
Also known as
3.4.24.79 · IGF-dependent IGFBP-4 protease · IGFBP-4ase · Insulin-like growth factor-dependent IGF-binding protein 4 protease · PAPP-A

Resolves to

Protein
UniProtQ13219UniProt namePAPP1_HUMAN
Gene
HGNCHGNC:8602NCBI Gene5069GeneCardsPAPPA
Pharmacology
KEGGhsa:5069
Structure
PDB7UFGPDB7Y5NPDB7Y5Q
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pappalysin-1, and which indications are they being tested in?

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