26S proteasome regulatory subunit 6A

BE0009032ProteinHumansPSMC3

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. It is acted on by 1 drug in DrugBank.

Gene name
PSMC3
UniProtKB entry
P17980Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
439 residues · 49,203 Da
Also known as
26S proteasome AAA-ATPase subunit RPT5 · Proteasome 26S subunit ATPase 3 · Proteasome subunit P50 · Tat-binding protein 1 · TBP-1

Resolves to

Protein
UniProtP17980UniProt namePRS6A_HUMAN
Gene
HGNCHGNC:9549NCBI Gene5702GeneCardsPSMC3
Pharmacology
KEGGhsa:5702
Structure
PDB5GJQPDB5GJRPDB5L4G
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 26S proteasome regulatory subunit 6A, and which indications are they being tested in?

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