Splicing factor 3A subunit 3

BE0009034ProteinHumansSF3A3

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). It is acted on by 1 drug in DrugBank.

Gene name
SF3A3
UniProtKB entry
Q12874Swiss-Prot
Cellular location
Nucleus speckle
Residues / weight
501 residues · 58,848 Da
Also known as
SAP 61 · SAP61 · SF3a60 · Spliceosome-associated protein 61

Resolves to

Protein
UniProtQ12874UniProt nameSF3A3_HUMAN
Gene
HGNCHGNC:10767NCBI Gene10946GeneCardsSF3A3
Pharmacology
KEGGhsa:10946
Structure
PDB2DT7PDB5Z56PDB5Z57
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Splicing factor 3A subunit 3, and which indications are they being tested in?

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