Ubiquitin carboxyl-terminal hydrolase 14

BE0009040ProteinHumansUSP14

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). It is acted on by 2 drugs in DrugBank.

Gene name
USP14
UniProtKB entry
P54578Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
494 residues · 56,069 Da
Also known as
3.4.19.12 · Deubiquitinating enzyme 14 · TGT · Ubiquitin thioesterase 14 · Ubiquitin-specific-processing protease 14

Resolves to

Protein
UniProtP54578UniProt nameUBP14_HUMAN
Gene
HGNCHGNC:12612NCBI Gene9097GeneCardsUSP14
Pharmacology
IUPHAR/GtoPdb2429KEGGhsa:9097
Structure
PDB2AYNPDB2AYOPDB5GJQ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin carboxyl-terminal hydrolase 14, and which indications are they being tested in?

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