Tachykinin-3
Details
- Name
- Tachykinin-3
- Kind
- protein
- Synonyms
- NKNB
- ZNEUROK1
- Gene Name
- TAC3
- UniProtKB Entry
- Q9UHF0Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049805|Tachykinin-3 MRIMLLFTAILAFSLAQSFGAVCKEPQEEVVPGGGRSKRDPDLYQLLQRLFKSHSSLEGL LKALSQASTDPKESTSPEKRDMHDFFVGLMGKRSVQPDSPTDVNQENVPSFGILKYPPRA E
- Number of residues
- 121
- Molecular Weight
- 13438.25
- Theoretical pI
- Not Available
- GO Classification
- Functionssignaling receptor bindingProcessespositive regulation of blood pressure
- General Function
- Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function
- Specific Function
- Signaling receptor binding
- Pfam Domain Function
- Neurokinin_B (PF03823)
- Signal Regions
- 1-16
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049806|Tachykinin-3 (TAC3) ATGAGGATCATGCTGCTATTCACAGCCATCCTGGCCTTCAGCCTAGCTCAGAGCTTTGGG GCTGTCTGTAAGGAGCCACAGGAGGAGGTGGTTCCTGGCGGGGGCCGCAGCAAGAGGGAT CCAGATCTCTACCAGCTGCTCCAGAGACTCTTCAAAAGCCACTCATCTCTGGAGGGATTG CTCAAAGCCCTGAGCCAGGCTAGCACAGATCCTAAGGAATCAACATCTCCCGAGAAACGT GACATGCATGACTTCTTTGTGGGACTTATGGGCAAGAGGAGCGTCCAGCCAGACTCTCCT ACGGATGTGAATCAAGAGAACGTCCCCAGCTTTGGCATCCTCAAGTATCCCCCGAGAGCA GAATAG
- Chromosome Location
- 12
- Locus
- 12q13.3
- External Identifiers
Resource Link UniProtKB ID Q9UHF0 UniProtKB Entry Name TKNK_HUMAN GeneCard ID TAC3 HGNC ID HGNC:11521 PDB ID(s) 1P9F, 8JBG KEGG ID hsa:6866 NCBI Gene ID 6866 - General References
- Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ: Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature. 2000 Jun 15;405(6788):797-800. [Article]
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- Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, Serin A, Mungan NO, Cook JR, Ozbek MN, Imamoglu S, Akalin NS, Yuksel B, O'Rahilly S, Semple RK: TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat Genet. 2009 Mar;41(3):354-8. doi: 10.1038/ng.306. Epub 2008 Dec 11. [Article]
- Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 2;92(5):725-43. doi: 10.1016/j.ajhg.2013.04.008. [Article]